Hyperhomocysteinemia and recurrent carotid stenosis

Hyperhomocysteinemia and recurrent carotid stenosis

Andreas Hillenbrand, Hillenbrand Renata, Liewald Florian, Zimmermann Julian
BMC Cardiovascular Disorders 2008, 8:1
Published: January 2008
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Conclusion
The effects of elevated plasma levels of homocysteine on the rate of CR are contradicting. Our finding suggests that high plasma homocysteine concentrations do not play a significant role in the development of restenosis following CEA. Additional studies are needed to investigate the impact of hyperhomocysteinemia on cardiovascular disease. A critical question in this context is whether the relationship between homocysteine levels and outcomes after vascular intervention is of causal nature. Elevated plasma levels of homocysteine could be a marker, rather than the cause for the respective disease [17].

Competing interests
The author(s) declare that they have no competing interests.

Authors' contributions
RH collected the samples and inquired data of patients.

AH performed literature review and performed the statistical analysis.

FL conceived of the study, participated in its design and coordination and helped to draft the manuscript.

JZ performed the duplex scan, conceived of the study, permit of ethical committee, helped to draft the manuscript.

Acknowledgements
We would like to thank Dr. Cihlar and Dr. Meiser for their support in collecting the blood samples and Ute Hartmann for patient management.

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