Fish Oils

Omega-3 fatty acids reduce the synthesis and secretion of very-low-density lipoprotein (VLDL) particles, and increase TG removal from VLDL and chylomicron particles through the upregulation of enzymes, such as lipoprotein lipase. They have a different mechanism of action to most drugs, and therefore have complementary benefits when administered with statins. They are particularly useful in patients with hypertriglyceridemia. Additional human studies are needed to define more clearly the cellular and molecular basis for the TG-lowering effects of omega-3 fatty acids and their favorable cardiovascular effects.