Nicotinic Acid Derivatives

Nicotinic acid derivatives

Niacin has been shown to delay the development of atherosclerosis by inhibiting hepatic secretion of VLDL39. Its mechanisms of action differ from those of statins, fibrates, and bile-sequestrants, allowing the potential for combination therapy to achieve synergistic effects. Niacin can be used effectively and safely in patients with type 2 diabetes mellitus, who often have low HDL levels40.

References:
  1. Meyers C.D. Kamanna V.S. Kashyap M.L. Niacin therapy in atherosclerosis Corr. Opin. Lipidol 2004 15(6):659-65 http://www.ncbi.nlm.nih.gov/pubmed/15529025
  2. 40. Bays H.E., Tighe A.P., Sadowvsky, R. Davidson M.H. Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications. Expert Rev. Cardiovasc. Ther. 2008 6(3):391-409. http://www.ncbi.nlm.nih.gov/pubmed/18327998

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