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Saturday, 10 May, 2008



Hot Topic
Study Of Lung Damage In Babies With Congenital Heart Disease
11 March 2008
Trying to understand and stop the collateral lung damage that can occur in babies with congenital heart disease is the focus of a new study. When a baby's heart defect results in too much blood in the lungs, more blood vessels are made, apparently to handle the increased volume, then new blood vessel growth is abruptly halted.

Further Reading
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A selection of must-have articles

Pediatric cardiology

Comparison of the epidemiology and co-morbidities of heart failure in the pediatric and adult populations: a retrospective, cross-sectional study
Heart failure is a clinical syndrome that affects both children and adults in the United States. HF in adults has received considerable attention, with multiple large, randomized trials that have evaluated the etiology and therapy of this condition.

Life Threatening Arrhythmias

Catheter Ablation of Tachyarrhythmias in Small Children
An estimated 80,000-100,000 radiofrequency ablation (RFA) procedures are performed in the United States each year. Approximately 1% of these are performed on pediatric patients at centers that contribute data to the Pediatric Radiofrequency Registry.

Medication

Getting It Right: Being Smarter about Clinical Trials
Concerns about adverse events, including deaths, in recent large clinical trials, both publicly and privately sponsored, prompted Elias A. Zerhouni, Director, National Institutes of Health (NIH) to convene a meeting at the NIH

Keeping you up to date with the latest clinical trial information

Pro-Calcitonin Levels Following Pediatric Cardiac Surgery

Emory University find out the PCT response to heart surgery in children by taking blood before surgery and each day for four days after surgery. These blood draws will help us figure out the typical PCT response, the normal increase in PCT after heart surgery, and when the PCT level returns to baseline.

Second, they hope to determine the accuracy of PCT as a marker of infection.

The hypothesis is that Procalcitonin is superior to other currently used markers of infection and will prove to be a clinically useful tool for evaluation of infection in children following cardiac surgery.

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Keeping you up to date with the latest clinical trial information

Pediatric Lead Extractability and Survival Evaluation (PLEASE)

The Children's Hospital Boston, Medtronic and the Guidant Corporation are conducting a randomized, prospective clinical trial comparing 2 different models of implantable cardioverter defibrillator (ICD) leads in children and patients with congenital heart disease. ICD lead survival in this patient group is particularly suboptimal, and lead extraction is technically difficult and carries a substantial morbidity risk. Recently, improved ICD lead designs have been released and are currently being utilized in patients. The main aim of the study is to determine if either type of lead performs better in terms of implantation electrical characteristics, long-term survival without breaking, and ease of extractability

Related Articles

Keeping you up to date with the latest clinical trial information

Resynchronization Therapy in Young Patients With and Without CH

A new treatment called Cardiac Resynchronization Therapy (CRT) is associated with biventricular pacing where two chambers of the heart are stimulated simultaneously. Tissue Doppler Imaging, Tissue Synchronization Imaging and 3 dimensional echocardiography are new forms of technology that look at the heart while it works. They are similar to a moving x-ray that can watch the heart muscles moving. The movement can be measured. In a trial sponsored by Emory University, doctors will check for changes that happen over time. This has not been studied in children before because this kind of is new to this group of patients. This technology is noninvasive which means it can be done from the outside of the body and is painless

Related Articles

Journal Watch
Selected headlines from the top Cardiology journals

Practicing paramedics cannot generate or estimate safe endotracheal tube cuff pressure using standard techniques

In a study to determine the ability of paramedics to generate or estimate safe endotracheal tube cuff pressure every paramedic inflated the cuff above the safe limit, and 87% could not detect an overinflated cuff by palpation of the pilot balloon. Prehosp Emerg Care 2007; Jul-Sep;11(3):307-11

Guidelines Watch
A round up of the latest Clinical Guidelines from the National Guideline Clearinghouse (NGC)

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